The solution is composed of a mixture of 3 mother tinctures at the same dilutions as the Sevene product Digeodren®. The study assesses the protective effects of Digeodren® on DNA lesions and the chromosomal mutations caused by mitomycin C. This medicine, used in the treatment of cancers, is known for its action on genotoxins.
This study was headed by Dr Carole Di Giorgio, biologist at the Biotoxicology and Environmental Mutagenesis Laboratory of the Faculty of Pharmacy, Aix/ Marseille. This laboratory is specialized in environmental toxins and the analysis of their impact on genetic mutations.
What is a genotoxic substance
and what are its effects ?
It is now widely recognised that environmental pollution is highly toxic for the human organism. This toxicity can take different forms :
- it is acute, and has immediate effects on people who are exposed to massive doses of pollutants (the Tchernobyl disaster in Ukraine, the Bhopal disaster in India…) ;
- it is chronic when people suffer from moderate doses of pollutants, which are easy to identify. Metabolic damage is often irreversible (for example farmers who are constantly exposed to pesticides) ;
- most people are exposed to low doses of pollutants. In this case, the toxicity is deferred, often for several years. Pollutants are difficult to identify (their effects add up) but damage is real and irreversible, and may be transmitted to the offspring – we then speak of genotoxicity.
Genotoxicity is therefore the result of the interaction of pollutants with DNA. Pollutants cause changes and ruptures in DNA. These mutations modify gene expression, and can induce many different pathologies – cancers, degenerative diseases… They also influence aging..
Among genotoxic agents are noted – metals, solvents, anticancer medication, pesticides, aromatic amines, ionizing radiation…
The protective effects in vitro for the 3-plant solution on the activity of a genotoxic agent
The objective of this study was to demonstrate the protective effects of the 3-plant solution composing Digeodren on the genotoxic agent mitomycin C.
The solution is composed of a mixture of 3 mother tinctures at the homeopathic dilutions contained in Digeodren® : dried bark of Berberis vulgaris (barberry root), entire fresh flowering plant of Taraxacum officinalis (dandelion) and fresh roots of Arctium lappa (burdock).
Cells are exposed to mitomycine C and to the plant solution (called DIG) according to 3 methods :
- as a preventive treatment (first DIG, then mitomycin C),
- as a simultaneous treatment (2 solutions combined),
- as a curative treatment (first mitomycin C, then DIG).
The DIG solution demonstrates an antimutagenic effect in both preventive and simultaneous treatment, due to a mixture of the active ingredients contained in the plants. Protection against the genotoxic effects of mitomycine C (breaches and loss of chromosomes) is between 40% and 60% in preventive and simultaneous treatment. There was no indication of a curative effect (the solution is not able to repair chromosomes). The 3 plants combined act in synergy, and demonstrate higher protective effects compared to that of a single plant.
An antimutagenic effect in preventive and simultaneous treatment
Does DIG solution protect an entire organism against genetoxic effect due to Mitomycine C ?
Dig solution has been administrated to rats during 72 hours before exposure to mitomycine C and 48 hours after exposure. DIG solution shows an antimutagenic effect on erythrocytes (red blood cells) inside rats liver, kidney, lung, brain, testes: it has a protective cellular against genotoxic agent which is mitomycine C. Over 80% protection with a 0.2% concentrated solution and almost 100% with a 2% concentration.
Global antimutagenic effect
The results of this study on a model in vivo attest to the fact that Digeodren® acts as a protective antigenotoxic regarding mitomycin C
These results can be explained by the different protective activities previously noted in extracts of 3 plants contained in the Digeodren formulation. Les effets pharmacologiques de ces 3 plantes sont reconnus dans la tradition :
- barberry has been used for more than 3,000 years in Chinese medicine for the treatment of hepatic troubles, and for the regulation of ;
- dandelion has been known since the 16th in Europe for the treatment of chronic liver problems ;
- burdock is widely used in both European and Chinese medicine for its detoxifying, antibacterial and draining effects.
The therapeutic potential of medicinal plants is vast and promising for emerging pathologies and diseases of civilisation.Currently, many scientific studies confirm the interest and the relevance of the use of traditional medicinal plants. Questions concerning ethical issues and the preservation of natural resources are indissociable from a respectful use of these plants.
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